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Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer.

Abstract
Estrogen receptor beta (ERβ) and TROP2 expressed in colon carcinoma and might play an important role there. We explored the relationship of ERβ and TROP2 expression with the prognosis of early-stage colon cancer. ERβ and TROP2 levels were assessed by immunohistochemistry in normal mucosa and tumoral tissues from 220 Chinese patients with T(3)N(0)M(0) (stage IIa) and T(4)N(0)M(0) (stage IIb) colon cancer in the Cancer Center, Sun Yat-sen University, who underwent curative surgical resection between 1995 and 2003. The Cox proportional hazards regression model was applied to analyze the overall survival (OS) data, and the ROC curve, Kaplan-Meier estimate, log rank test, and Jackknife method were used to show the effect of ERβ and TROP2 expression at different stages of cancer. The 5-year survival rates were not significantly different between the patients with stage IIa and stage IIb colon cancer (83 vs. 80 %, respectively). The high expression of ERβ was related to decreasing OS in stage IIa and stage IIb colon cancer, while the high expression of TROP2 was related to decreasing OS in stage IIb colon cancer. The expression of ERβ and TROP2 has tumor-suppressive and tumor-promoting effect in stage IIa and stage IIb colon cancer, respectively.
AuthorsYu-Jing Fang, Guo-Qiang Wang, Zhen-Hai Lu, Lin Zhang, Ji-Bin Li, Xiao-Jun Wu, Pei-Rong Ding, Qing-Jian Ou, Mei-Fang Zhang, Wu Jiang, Zhi-Zhong Pan, De-Sen Wan
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 33 Issue 6 Pg. 2227-35 (Dec 2012) ISSN: 1423-0380 [Electronic] Netherlands
PMID23055188 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • Estrogen Receptor beta
  • TACSTD2 protein, human
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm (metabolism)
  • Biomarkers, Tumor (metabolism)
  • Case-Control Studies
  • Cell Adhesion Molecules (metabolism)
  • Child
  • Colon (metabolism, pathology)
  • Colonic Neoplasms (metabolism, mortality, pathology)
  • Estrogen Receptor beta (metabolism)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoenzyme Techniques
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Prognosis
  • Survival Rate
  • Young Adult

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