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Diagnostic usefulness of a T-cell-based assay in patients with miliary tuberculosis compared with those with lymph node tuberculosis.

Abstract
Forty-three patients with miliary tuberculosis were evaluated for diagnostic usefulness of enzyme-linked immunospot (ELISPOT) assay. Among noninvasive rapid tests available within 3-5 days, ELISPOT had the highest sensitivity (93%), compared with acid-fast bacilli stain (sputum, 32% and bronchoalveolar lavage, 7%), Mycobacterium tuberculosis polymerase chain reaction (sputum, 53% and bronchoalveolar lavage, 36%), and tuberculin skin test (22%). In comparison with 44 patients with lymph node tuberculosis, the sensitivity of the ELISPOT assay in patients with miliary tuberculosis (93%) was as high as in those with lymph node tuberculosis (95%, P = .63), whereas the sensitivity of the tuberculin skin test was substantially lower in patients with miliary tuberculosis (22%) than in those with lymph node tuberculosis (73%, P < .001).
AuthorsYu-Mi Lee, Ki-Ho Park, Sun-Mi Kim, Su Jin Park, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 56 Issue 2 Pg. e26-9 (Jan 2013) ISSN: 1537-6591 [Electronic] United States
PMID23051762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Bacterial
  • Bacterial Proteins
  • CFP-10 protein, Mycobacterium tuberculosis
  • ESAT-6 protein, Mycobacterium tuberculosis
Topics
  • Antigens, Bacterial (immunology)
  • Bacterial Proteins (immunology)
  • Enzyme-Linked Immunospot Assay
  • Humans
  • Sensitivity and Specificity
  • T-Lymphocytes (immunology, metabolism)
  • Tuberculin Test
  • Tuberculosis, Lymph Node (diagnosis, immunology, metabolism)
  • Tuberculosis, Miliary (diagnosis, immunology, metabolism)

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