Abstract |
Forty-three patients with miliary tuberculosis were evaluated for diagnostic usefulness of enzyme-linked immunospot (ELISPOT) assay. Among noninvasive rapid tests available within 3-5 days, ELISPOT had the highest sensitivity (93%), compared with acid-fast bacilli stain (sputum, 32% and bronchoalveolar lavage, 7%), Mycobacterium tuberculosis polymerase chain reaction (sputum, 53% and bronchoalveolar lavage, 36%), and tuberculin skin test (22%). In comparison with 44 patients with lymph node tuberculosis, the sensitivity of the ELISPOT assay in patients with miliary tuberculosis (93%) was as high as in those with lymph node tuberculosis (95%, P = .63), whereas the sensitivity of the tuberculin skin test was substantially lower in patients with miliary tuberculosis (22%) than in those with lymph node tuberculosis (73%, P < .001).
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Authors | Yu-Mi Lee, Ki-Ho Park, Sun-Mi Kim, Su Jin Park, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 56
Issue 2
Pg. e26-9
(Jan 2013)
ISSN: 1537-6591 [Electronic] United States |
PMID | 23051762
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Bacterial
- Bacterial Proteins
- CFP-10 protein, Mycobacterium tuberculosis
- ESAT-6 protein, Mycobacterium tuberculosis
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Topics |
- Antigens, Bacterial
(immunology)
- Bacterial Proteins
(immunology)
- Enzyme-Linked Immunospot Assay
- Humans
- Sensitivity and Specificity
- T-Lymphocytes
(immunology, metabolism)
- Tuberculin Test
- Tuberculosis, Lymph Node
(diagnosis, immunology, metabolism)
- Tuberculosis, Miliary
(diagnosis, immunology, metabolism)
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