Abstract | INTRODUCTION: In this study we retrospectively reviewed data on 311 consecutive elective cholecystectomies, performed for benign disease ( cholelithiasis, cholecystitis) in our institution in the last six years, in order to determine the frequency of unexpected gallbladder pre-neoplastic and neoplastic lesions and analyse their clinical, diagnostic and therapeutic features. MATERIALS AND METHODS: Three hundred eleven consecutive patients underwent elective cholecystectomy for benign gallbladder disease in our Institution from January 2005 to March 2011. Clinical records and histo-pathological reports were reviewed in order to detect occult gallbladder pre-neoplastic and neoplastic lesions and describe the clinical, diagnostic and therapeutic findings. Eight patients were excluded for lacking of important clinical data. RESULTS: Out of 303 patients examined, 26 (8.6%) were found to be affected by a concomitant pre-neoplastic or neoplastic lesion. Ten (3.3%) were found to have a benign lesion, 13 (4.3%) a dysplasia of the gallbladder epithelium and 3 (1%) a gallbladder adenocarcinoma. DISCUSSION: Dysplasia was found in 4,3% of cases and surgery represents the interruption of an eventual malignant evolution. Adenomiomatosis and adenomas represent the most frequent benign occult lesions discovered; surgery is the definitive cure for such lesions. Occult gallbladder adenocarcinoma was detected in 1% of cases in absence of any preoperative clinical or radiological suspect. Cholecystectomy is curative in stage T1a disease, while a re-resection is necessary for more invasive non metastatic disease.
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Authors | Panagiotis Paliogiannis, Fabrizio Scognamillo, Federico Attene, Antonio Marrosu, Emilio Trignano, Laura Tedde, Daniele Delogu, Mario Trignano |
Journal | Annali italiani di chirurgia
(Ann Ital Chir)
2013 May-Jun
Vol. 84
Issue 3
Pg. 281-5
ISSN: 2239-253X [Electronic] Italy |
PMID | 23047610
(Publication Type: Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cholecystectomy
(methods)
- Cholecystitis
(surgery)
- Cholelithiasis
(surgery)
- Elective Surgical Procedures
- Female
- Gallbladder Neoplasms
(diagnosis, epidemiology)
- Humans
- Incidental Findings
- Male
- Middle Aged
- Precancerous Conditions
(diagnosis, epidemiology)
- Retrospective Studies
- Video-Assisted Surgery
- Young Adult
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