Abstract |
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.
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Authors | Haruyo Nakajima-Adachi, Emiko Koike, Mamoru Totsuka, Erika Hiraide, Yoshio Wakatsuki, Hiroshi Kiyono, Satoshi Hachimura |
Journal | Bioscience, biotechnology, and biochemistry
(Biosci Biotechnol Biochem)
Vol. 76
Issue 10
Pg. 1979-81
( 2012)
ISSN: 1347-6947 [Electronic] England |
PMID | 23047087
(Publication Type: Journal Article)
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Chemical References |
- Epitopes
- Peptide Fragments
- Ovalbumin
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Topics |
- Amino Acid Sequence
- Animals
- CD4-Positive T-Lymphocytes
(cytology, immunology)
- Cell Differentiation
(immunology)
- Epitopes
(chemistry, immunology)
- Food Hypersensitivity
(immunology)
- Mice
- Molecular Sequence Data
- Ovalbumin
(chemistry)
- Peptide Fragments
(chemistry, immunology)
- Phenotype
- Th1 Cells
(cytology)
- Th2 Cells
(cytology)
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