Abstract | BACKGROUND: METHODS: RESULTS: Compared with controls, the CKD rats exhibited hypertriglyceridemia, elevated plasma and liver tissue free fatty acids, increased nuclear ChREBP and reduced nuclear SREBP-1 and PPARα, upregulation of ACC and FAS and downregulation of L-FABP, CPT1A, ATP synthase α, glycogen synthase and DGAT in the liver tissue. CONCLUSION: Liver in animals with advanced CKD exhibits ChREBP-mediated upregulation of enzymes involved in fatty acid synthesis, downregulation of PPARα-regulated fatty acid oxidation system and reduction of DGAT resulting in reduced fatty acid incorporation in triglyceride.
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Authors | Kyubok Jin, Keith Norris, Nosratola D Vaziri |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 28
Issue 2
Pg. 313-20
(Feb 2013)
ISSN: 1460-2385 [Electronic] England |
PMID | 23045433
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Fatty Acids
- Mlxipl protein, rat
- PPAR gamma
- Triglycerides
- Dgat1 protein, rat
- Diacylglycerol O-Acyltransferase
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Topics |
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
(metabolism)
- Diacylglycerol O-Acyltransferase
(metabolism)
- Disease Models, Animal
- Fatty Acids
(metabolism)
- Liver
(metabolism)
- Male
- PPAR gamma
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Renal Insufficiency, Chronic
(metabolism, physiopathology)
- Triglycerides
(metabolism)
|