Ineffectiveness and comparative pathogenicity of attenuated rabies virus vaccines for the striped skunk (Mephitis mephitis).

Abstract

Three attenuated rabies virus vaccines (SAD-B19, ERA/BHK-21, AZA 2) were compared for efficacy and safety in the striped skunk (Mephitis mephitis) by the oral and intranasal routes. The SAD-B19 and ERA/BHK-21 vaccines were given orally; all three vaccines were given intranasally. Oral administration of SAD-B19 and ERA/BHK-21 vaccines induced neither seroconversion nor significant protection against rabies challenge. One skunk which consumed a SAD-B19 vaccine-laden bait succumbed to vaccine-induced rabies. Intranasal instillation of the three vaccines resulted in the deaths of two of six (AZA 2), three of six (ERA/BHK-21) and six of six (SAD-B19) skunks.

• Authors: C E Rupprecht, K M Charlton, M Artois, G A Casey, W A Webster, J B Campbell, K F Lawson, L G Schneider
• Journal: Journal of wildlife diseases (J Wildl Dis) Vol. 26 Issue 1 Pg. 99-102 (Jan 1990) ISSN: 0090-3558 [Print] United States
• PMID: 2304207 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral
• Rabies Vaccines
• Vaccines, Attenuated

Topics

• Administration, Intranasal
• Administration, Oral
• Animals
• Antibodies, Viral (biosynthesis)
• Carnivora
• Female
• Male
• Mephitidae
• Rabies (prevention & control, veterinary)
• Rabies Vaccines (administration & dosage, adverse effects, immunology)
• Rabies virus (immunology)
• Vaccines, Attenuated (administration & dosage, adverse effects, immunology)