Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Hepatic fibrosis, a precursor of liver cirrhosis, is a consequence of severe liver damage that occurs in many patients with chronic liver diseases. Salvianolic acid B (SA-B) is one of water soluble compounds derived from Salvia miltiorrhiza Bunge (Danshen in Chinese) widely used for chronic liver diseases. In this study we investigated the protective effects of SA-B on CCl(4)-induced hepatic fibrosis. MATERIALS AND METHODS: RESULTS: SA-B was shown to reduce CCl(4)-induced hepatic fibrosis in rats. The serum levels of ALT, AST, and TBIL were significantly lower in the SA-B treatment groups than in the M group. Compared the M group, the serum levels of HA, LN, IV-C and PIIIP were decreased markedly after treatment with SA-B, especially in the H group. Treatment with SA-B at 10-20mg/kg (L and N groups, respectively) dose-dependently decreased the expression of NF-κB in the nucleolus and increased the expression levels of NF-κB and IκBα protein in the cytoplasm compared to that of the M group. CONCLUSIONS: This study reveals that SA-B could prevent the progression of liver angiogenesis and alleviate liver fibrosis possibly by regulating the expression of NF-κB and IκBα.
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Authors | Rong Wang, Xiao-Yan Yu, Zhu-Ying Guo, Yu-Jie Wang, Yan Wu, Yong-Fang Yuan |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 144
Issue 3
Pg. 592-8
(Dec 18 2012)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23041223
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Crown Copyright © 2012. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Benzofurans
- Collagen Type IV
- I-kappa B Proteins
- Laminin
- NF-kappa B
- Nfkbia protein, rat
- Peptide Fragments
- Procollagen
- Protective Agents
- procollagen Type III-N-terminal peptide
- NF-KappaB Inhibitor alpha
- Hyaluronic Acid
- salvianolic acid B
- Carbon Tetrachloride
- Aspartate Aminotransferases
- Alanine Transaminase
- Bilirubin
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- Benzofurans
(pharmacology, therapeutic use)
- Bilirubin
(blood)
- Carbon Tetrachloride
- Collagen Type IV
(blood)
- Hyaluronic Acid
(blood)
- I-kappa B Proteins
(metabolism)
- Laminin
(blood)
- Liver Cirrhosis, Experimental
(chemically induced, drug therapy, metabolism, pathology)
- Male
- NF-KappaB Inhibitor alpha
- NF-kappa B
(metabolism)
- Peptide Fragments
(blood)
- Procollagen
(blood)
- Protective Agents
(pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Salvia
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