Plasma trough levels of adalimumab and infliximab in terms of clinical efficacy during the treatment of psoriasis.

Abstract

We examined the relation between adalimumab and infliximab plasma trough levels, anti-adalimumab and anti-infliximab antibody formation. We analyzed plasma from 32 adalimumab-treated and 20 infliximab-treated psoriasis patients for evaluating trough levels of each drug. The presence of anti-adalimumab and anti-infliximab antibodies was analyzed and the severity of psoriasis was evaluated. At week 28, 25 out of 32 and at week 48, 21 out of 30 adalimumab-treated patients maintained as more than PASI 75. At week 28, 12 out of 20 and at week 48, nine out of 18 infliximab-treated patients were evaluated as more than PASI 75. In patients treated with 40 mg adalimumab every other week, the mean trough level was 7.62 μg/mL (range, 0.05-10.6) at week 48. In patients treated with 80 mg adalimumab every other week, the mean trough level was 8.61 μg/mL (range, 0.08-13.5) at week 48. Mean trough level of infliximab-treated cases (4.1-5.2 mg/kg; mean, 4.6) was 4.64 μg/mL (range, 0.03-16.9) at week 48. Anti-adalimumab antibody was detected in five out of 32 cases and anti-infliximab antibody was detected in six out of 20 cases, respectively, at weeks 24 and 48. The optimal cut-off values of adalimumab and infliximab concentration for more than PASI 75 were more than 7.84 μg/mL and more than 0.92 μg/mL, respectively. The trough levels of adalimumab and infliximab in psoriasis patients were positively associated with clinical response and were significantly lower in cases having anti-adalimumab or anti-infliximab antibodies.

• Authors: Hidetoshi Takahashi, Hitomi Tsuji, Akemi Ishida-Yamamoto, Hajime Iizuka
• Journal: The Journal of dermatology (J Dermatol) Vol. 40 Issue 1 Pg. 39-42 (Jan 2013) ISSN: 1346-8138 [Electronic] England
• PMID: 23039179 (Publication Type: Journal Article)
• Copyright: © 2012 Japanese Dermatological Association.

Chemical References

• Antibodies, Anti-Idiotypic
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Dermatologic Agents
• Infliximab
• Adalimumab

Topics

• Adalimumab
• Aged
• Antibodies, Anti-Idiotypic (blood)
• Antibodies, Monoclonal (immunology, therapeutic use)
• Antibodies, Monoclonal, Humanized (immunology, therapeutic use)
• Dermatologic Agents (immunology, therapeutic use)
• Female
• Humans
• Infliximab
• Male
• Middle Aged
• Psoriasis (drug therapy, immunology)
• Severity of Illness Index
• Treatment Outcome