MR characterization of focal nodular hyperplasia: gadoxetic acid versus superparamagnetic iron oxide imaging.

Abstract

PURPOSE:

We evaluated the diagnostic efficacy of gadoxetic acid- and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for focal nodular hyperplasia (FNH).

MATERIALS AND METHODS:

We retrospectively evaluated 11 patients with 11 FNHs. Both gadoxetic acid- and SPIO-enhanced MR imaging were performed. A 3-dimensional (3D) volumetric interpolated breath-hold examination was used with the gadoxetic acid dynamic study. SPIO-enhanced MR imaging included T₂- and T₂*-weighted images. We quantitatively and qualitatively compared lesion-specific enhancement of both contrast media.

RESULTS:

The mean signal-to-noise (S/N) ratio of the FNH lesions differed significantly on pre- and postenhanced imaging of each contrast medium (P<0.05); mean contrast-to-noise (C/N) ratio did not (P>0.05). All observers described all lesions as hyperintense in the arterial phase on gadoxetic acid-enhanced MR imaging and observed the presence of central scar, fibrous septa, and rim most clearly in gadoxetic acid-enhanced hepatobiliary phase images.

CONCLUSION:

Gadoxetic acid-enhanced MR imaging was more useful than SPIO-enhanced MR imaging in characterizing FNH.

• Authors: Kazuhiro Saito, Nobutaka Yoshimura, Toru Saguchi, Jinho Park, Katsutoshi Sugimoto, Soichi Akata, Fuminori Moriyasu, Koichi Tokuuye
• Journal: Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine (Magn Reson Med Sci) Vol. 11 Issue 3 Pg. 163-9 ( 2012) ISSN: 1880-2206 [Electronic] Japan
• PMID: 23037560 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Contrast Media
• Dextrans
• Magnetite Nanoparticles
• ferumoxtran-10
• gadolinium ethoxybenzyl DTPA
• Gadolinium DTPA

Topics

• Adult
• Aged
• Contrast Media
• Dextrans
• Female
• Focal Nodular Hyperplasia (pathology)
• Gadolinium DTPA
• Humans
• Magnetic Resonance Imaging (methods)
• Magnetite Nanoparticles
• Male
• Middle Aged
• Reproducibility of Results
• Retrospective Studies
• Sensitivity and Specificity