Abstract | BACKGROUND: METHODS: RESULTS:
Glycodelin A was found to be an independent prognostic marker for poor prognosis in advanced ovarian cancer patients. GdA staining correlated with gonadotropin receptor (FSHR and LHCGR) and with hCG expression. Gd expression showed a positive correlation with a tumour-associated epitope of mucin 1 (TA-MUC1). Further, compared to ovarian cancer, serum Gd was increased in patients with benign ovarian tumors. CONCLUSION:
Glycodelin A might be related to tumor aggressiveness and poor clinical outcome in advanced epithelial ovarian cancer. Glycodelin serum levels found in patients suffering from benign ovarian tumors, might contribute to a more global attenuation during progression of these precursor lesions.
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Authors | Christoph Scholz, Sabine Heublein, Miriam Lenhard, Klaus Friese, Doris Mayr, Udo Jeschke |
Journal | BMC research notes
(BMC Res Notes)
Vol. 5
Pg. 551
(Oct 05 2012)
ISSN: 1756-0500 [Electronic] England |
PMID | 23036050
(Publication Type: Journal Article)
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Chemical References |
- Antibodies
- Biomarkers, Tumor
- Glycodelin
- Glycoproteins
- Mucin-1
- PAEP protein, human
- Receptors, Gonadotropin
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Topics |
- Antibodies
(chemistry)
- Biomarkers, Tumor
(blood, metabolism)
- Carcinoma
(diagnosis, metabolism, mortality, pathology)
- Carcinoma, Ovarian Epithelial
- Female
- Gene Expression
- Glycodelin
- Glycoproteins
(blood, metabolism)
- Humans
- Immunohistochemistry
- Mucin-1
(metabolism)
- Neoplasm Grading
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
(diagnosis, metabolism, mortality, pathology)
- Ovarian Neoplasms
(diagnosis, metabolism, mortality, pathology)
- Prognosis
- Receptors, Gonadotropin
(metabolism)
- Survival Analysis
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