Abstract | AIM: The aim of this study was to evaluate the effect of the surface functionalization of model nanoparticles on their mobility in bacterial biofilms and cystic fibrosis sputum. MATERIALS & METHODS: RESULTS: PEGylation increased the mobility of the particles in sputum and biofilms, while the charged nanospheres were strongly immobilized. However, the transport of the PEGylated nanoparticles was lower in sputum compared with biofilms. Furthermore, the particle transport showed heterogeneity in samples originating from different patients. CONCLUSION: This study's data suggest that for future nanocarrier design it will be essential to combine PEGylation with a targeting moiety to ensure sufficient mobility in mucus and a better accumulation of the nanoparticles in the biofilm.
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Authors | Katrien Forier, Anne-Sophie Messiaen, Koen Raemdonck, Hendrik Deschout, Joanna Rejman, Frans De Baets, Hans Nelis, Stefaan C De Smedt, Joseph Demeester, Tom Coenye, Kevin Braeckmans |
Journal | Nanomedicine (London, England)
(Nanomedicine (Lond))
Vol. 8
Issue 6
Pg. 935-49
(Jun 2013)
ISSN: 1748-6963 [Electronic] England |
PMID | 23035662
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Biofilms
- Burkholderia
(physiology)
- Burkholderia Infections
(microbiology)
- Child
- Cystic Fibrosis
(metabolism)
- Female
- Humans
- Male
- Motion
- Nanoparticles
(analysis, metabolism)
- Polyethylene Glycols
(analysis, metabolism)
- Pseudomonas Infections
(microbiology)
- Pseudomonas aeruginosa
(physiology)
- Sputum
(metabolism)
- Surface Properties
- Young Adult
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