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Systemic contact dermatitis to corticosteroids.

AbstractBACKGROUND:
Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic administration of corticosteroids may exceptionally be involved.
OBJECTIVE:
To determine the frequency, clinical presentation and cross-reactivity patterns for allergic reactions following systemic administration of corticosteroids amongst patients with identified and investigated 'contact allergy' to corticosteroids.
METHODS:
We reviewed clinical data, patch test results and sensitization sources in patients who reacted positively to corticosteroids tested in the K.U. Leuven Dermatology department during an 18-year period.
RESULTS:
Sixteen subjects (out of 315 with CS delayed-type hypersensitivity) presented with allergic manifestations due to systemic administration of corticosteroids. Most patients reacted to molecules from the three groups of the recently reappraised classification.
CONCLUSION:
The reactions observed seem to be in most cases 'systemic contact dermatitis' due to oral or parenteral re-exposure of sensitized individuals with the respective corticosteroids previously applied topically. Moreover, most patients seem to be able to react to any corticosteroid molecules and therefore need a systematic individualized evaluation of their sensitization/tolerance profile.
AuthorsM Baeck, A Goossens
JournalAllergy (Allergy) Vol. 67 Issue 12 Pg. 1580-5 (Dec 2012) ISSN: 1398-9995 [Electronic] Denmark
PMID23033862 (Publication Type: Journal Article)
Copyright© 2012 John Wiley & Sons A/S.
Chemical References
  • Adrenal Cortex Hormones
Topics
  • Adrenal Cortex Hormones (administration & dosage, adverse effects, chemistry)
  • Adult
  • Aged
  • Cross Reactions (immunology)
  • Dermatitis, Allergic Contact (diagnosis, epidemiology)
  • Drug Eruptions (diagnosis)
  • Drug Hypersensitivity (diagnosis, epidemiology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prevalence

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