Abstract | BACKGROUND: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic administration of corticosteroids may exceptionally be involved. OBJECTIVE: METHODS: We reviewed clinical data, patch test results and sensitization sources in patients who reacted positively to corticosteroids tested in the K.U. Leuven Dermatology department during an 18-year period. RESULTS: Sixteen subjects (out of 315 with CS delayed-type hypersensitivity) presented with allergic manifestations due to systemic administration of corticosteroids. Most patients reacted to molecules from the three groups of the recently reappraised classification. CONCLUSION: The reactions observed seem to be in most cases 'systemic contact dermatitis' due to oral or parenteral re-exposure of sensitized individuals with the respective corticosteroids previously applied topically. Moreover, most patients seem to be able to react to any corticosteroid molecules and therefore need a systematic individualized evaluation of their sensitization/tolerance profile.
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Authors | M Baeck, A Goossens |
Journal | Allergy
(Allergy)
Vol. 67
Issue 12
Pg. 1580-5
(Dec 2012)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 23033862
(Publication Type: Journal Article)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, adverse effects, chemistry)
- Adult
- Aged
- Cross Reactions
(immunology)
- Dermatitis, Allergic Contact
(diagnosis, epidemiology)
- Drug Eruptions
(diagnosis)
- Drug Hypersensitivity
(diagnosis, epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Prevalence
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