Abstract | PURPOSE: EXPERIMENTAL DESIGN: The effects of N-BPs on Vγ9Vδ2 T-cell expansion and anticancer activity were evaluated in vitro and in animal models of human breast cancers. The modalities of recognition of breast tumors by Vγ9Vδ2 T cells in N-BP-treated animals were also examined. RESULTS: CONCLUSION: These findings suggest that N-BPs can have an adjuvant role in cancer therapy by activating Vγ9Vδ2 T-cell cytotoxicity in patients with breast cancer that produces high IPP/ApppI levels after N-BP treatment.
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Authors | Ismahène Benzaïd, Hannu Mönkkönen, Edith Bonnelye, Jukka Mönkkönen, Philippe Clézardin |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 18
Issue 22
Pg. 6249-59
(Nov 15 2012)
ISSN: 1557-3265 [Electronic] United States |
PMID | 23032740
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | ©2012 AACR. |
Chemical References |
- Antigens, Neoplasm
- Antineoplastic Agents
- Hemiterpenes
- Immunologic Factors
- Organophosphorus Compounds
- Receptors, Antigen, T-Cell, gamma-delta
- Intercellular Adhesion Molecule-1
- isopentenyl pyrophosphate
- Geranyltranstransferase
- Risedronic Acid
- Etidronic Acid
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Topics |
- Animals
- Antigens, Neoplasm
(immunology, metabolism)
- Antineoplastic Agents
(pharmacology)
- Breast Neoplasms
(drug therapy, immunology, metabolism)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cytotoxicity, Immunologic
(drug effects)
- Etidronic Acid
(analogs & derivatives, pharmacology)
- Female
- Geranyltranstransferase
(metabolism)
- Hemiterpenes
(immunology, metabolism)
- Humans
- Immunologic Factors
(pharmacology)
- Intercellular Adhesion Molecule-1
(metabolism)
- Leukocytes, Mononuclear
(drug effects)
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Organophosphorus Compounds
(immunology, metabolism)
- Receptors, Antigen, T-Cell, gamma-delta
(metabolism)
- Risedronic Acid
- T-Lymphocytes, Cytotoxic
(drug effects, immunology, metabolism)
- Xenograft Model Antitumor Assays
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