Substance of abuse and movement disorders: complex interactions and comorbidities.

Abstract

The relationship between movement disorders and substance abuse, which we previously reviewed, is updated. We examine these relationships bidirectionally with focus on drugs of abuse that are known to cause movement disorders, as well as primary movement disorders that are associated with use and abuse of alcohol and dopaminergic medications. First, we review the movement disorders that may develop from the acute use or withdrawal of frequent drugs of abuse, including alcohol, cocaine, heroin, amphetamine and methcathinone. We then comment on the interaction between alcoholism and alcohol-responsive movement disorders, such as essential tremor and myoclonus-dystonia. Lastly, we discuss the potential for abuse of antiparkinsonian dopaminergic agents in patients with Parkinson's disease (PD).

• Authors: Andres Deik, Rachel Saunders-Pullman, Marta San Luciano
• Journal: Current drug abuse reviews (Curr Drug Abuse Rev) Vol. 5 Issue 3 Pg. 243-53 (Sep 2012) ISSN: 1874-4745 [Electronic] United Arab Emirates
• PMID: 23030352 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Antiparkinson Agents
• Dopamine Agents
• Dopamine

Topics

• Alcoholism (complications)
• Animals
• Antiparkinson Agents (administration & dosage, adverse effects)
• Dopamine (metabolism)
• Dopamine Agents (administration & dosage, adverse effects)
• Humans
• Movement Disorders (etiology, physiopathology)
• Parkinson Disease (drug therapy)
• Substance Withdrawal Syndrome (physiopathology)
• Substance-Related Disorders (complications)