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Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice.

Abstract
Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl(4)) and the mechanisms involved were investigated. Intraperitoneal injection of CCl(4) (50 µl/kg) resulted in a significant increase in the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and hepatic malondialdehyde (MDA), also a marked enhancement in the expression of hepatic tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and nuclearfactor-kappa B (NF-κB). On the other hand, decreased glutathione (GSH) content and activities of glutathione transferase (GST), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were observed following CCl(4) exposure. Nevertheless, all of these phenotypes were evidently reversed by preadministration of polydatin for 5 continuous days. The mRNA and protein expression levels of hepatic growth factor-beta1 (TGF-β(1)) were enhanced further by polydatin. These results suggest that polydatin protects mice against CCl(4)-induced liver injury through antioxidant stress and antiinflammatory effects. Polydatin may be an effective hepatoprotective agent and a promising candidate for the treatment of oxidative stress- and inflammation-related diseases.
AuthorsHong Zhang, Cheng-Hao Yu, Yi-Ping Jiang, Cheng Peng, Kun He, Jian-Yuan Tang, Hai-Liang Xin
JournalPloS one (PLoS One) Vol. 7 Issue 9 Pg. e46574 ( 2012) ISSN: 1932-6203 [Electronic] United States
PMID23029551 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Antioxidants
  • Drugs, Chinese Herbal
  • Glucosides
  • Inflammation Mediators
  • NF-kappa B
  • Stilbenes
  • Transforming Growth Factor beta1
  • Carbon Tetrachloride
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Transferase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Glutathione
  • polydatin
Topics
  • Alanine Transaminase (blood)
  • Animals
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Antioxidants (pharmacology, therapeutic use)
  • Aspartate Aminotransferases (blood)
  • Carbon Tetrachloride
  • Catalase (metabolism)
  • Drug-Induced Liver Injury (blood, drug therapy, pathology)
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Fallopia japonica (chemistry)
  • Gene Expression
  • Glucosides (pharmacology, therapeutic use)
  • Glutathione (metabolism)
  • Glutathione Peroxidase (metabolism)
  • Glutathione Transferase (metabolism)
  • Inflammation Mediators (metabolism)
  • Liver (drug effects, enzymology, metabolism)
  • Male
  • Mice
  • Mice, Inbred ICR
  • NF-kappa B (metabolism)
  • Oxidative Stress (drug effects)
  • Stilbenes (pharmacology, therapeutic use)
  • Superoxide Dismutase (metabolism)
  • Transforming Growth Factor beta1 (genetics, metabolism)
  • Up-Regulation

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