Abstract | BACKGROUND: METHODOLOGY: FINDINGS: CONCLUSIONS: Our results show that oxidative stress occurs locally and systemically in obese rats with pancreatitis favouring inactivation of protein phosphatases in pancreas, which would promote up-regulation of pro-inflammatory cytokines, and the increase of isoprostanes which might cause powerful pulmonary and renal vasoconstriction. Future studies are needed to confirm the translational relevance of the present findings obtained in a rat model of taurocholate-induced pancreatic damage and necrosis.
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Authors | Javier Pereda, Salvador Pérez, Javier Escobar, Alessandro Arduini, Miguel Asensi, Gaetano Serviddio, Luis Sabater, Luis Aparisi, Juan Sastre |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 9
Pg. e44383
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23028532
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoprostanes
- Triglycerides
- Malondialdehyde
- Taurocholic Acid
- Glutathione
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Topics |
- Animals
- Blotting, Western
- Glutathione
(metabolism)
- Isoprostanes
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Obesity
(metabolism, physiopathology)
- Oxidative Stress
- Pancreas
(enzymology, metabolism, pathology)
- Pancreatitis, Acute Necrotizing
(chemically induced, metabolism, pathology)
- Rats
- Rats, Zucker
- Taurocholic Acid
(toxicity)
- Triglycerides
(metabolism)
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