PPARs Signaling and Cancer in the Gastrointestinal System.

Abstract

Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.

• Authors: Valerio Pazienza, Manlio Vinciguerra, Gianluigi Mazzoccoli
• Journal: PPAR research (PPAR Res) Vol. 2012 Pg. 560846 ( 2012) ISSN: 1687-4765 [Electronic] United States
• PMID: 23028383 (Publication Type: Journal Article)