Successful combination treatment of a patient with progressive juvenile localized scleroderma (morphea) using imatinib, corticosteroids, and methotrexate.

Abstract

We report a case of progressive juvenile localized scleroderma (JLS or morphea) treated with a combination of imatinib, corticosteroids, and methotrexate. This therapy halted the progressive skin thickening and the hand and finger joint deformity in the early stages of the disease. We conclude that imatinib used in addition to standard treatment with systemic corticosteroids and methotrexate may be of therapeutic benefit for individuals with JLS.

• Authors: Yasuji Inamo, Toyoko Ochiai
• Journal: Pediatric dermatology (Pediatr Dermatol) 2013 Nov-Dec Vol. 30 Issue 6 Pg. e191-3 ISSN: 1525-1470 [Electronic] United States
• PMID: 23025697 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 Wiley Periodicals, Inc.

Chemical References

• Adrenal Cortex Hormones
• Benzamides
• Immunosuppressive Agents
• Piperazines
• Protein Kinase Inhibitors
• Pyrimidines
• Imatinib Mesylate
• Methotrexate

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Benzamides (therapeutic use)
• Child, Preschool
• Drug Therapy, Combination
• Female
• Hand Dermatoses (drug therapy)
• Humans
• Imatinib Mesylate
• Immunosuppressive Agents (therapeutic use)
• Methotrexate (therapeutic use)
• Piperazines (therapeutic use)
• Protein Kinase Inhibitors (therapeutic use)
• Pyrimidines (therapeutic use)
• Scleroderma, Localized (drug therapy)
• Treatment Outcome