Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.

Abstract

MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.

• Authors: Vinod Kumar, Paulisally Hau Yi Lo, Hiromi Sawai, Naoya Kato, Atsushi Takahashi, Zhenzhong Deng, Yuji Urabe, Hamdi Mbarek, Katsushi Tokunaga, Yasuhito Tanaka, Masaya Sugiyama, Masashi Mizokami, Ryosuke Muroyama, Ryosuke Tateishi, Masao Omata, Kazuhiko Koike, Chizu Tanikawa, Naoyuki Kamatani, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda
• Journal: PloS one (PLoS One) Vol. 7 Issue 9 Pg. e44743 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 23024757 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Histocompatibility Antigens Class I
• MHC class I-related chain A

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood, genetics)
• Carcinoma, Hepatocellular (blood, genetics, mortality, virology)
• Female
• Hepatitis B virus
• Histocompatibility Antigens Class I (blood, genetics)
• Humans
• Liver Neoplasms (blood, genetics, mortality, virology)
• Male
• Middle Aged
• Minisatellite Repeats
• Neovascularization, Pathologic (blood, genetics)
• Polymorphism, Single Nucleotide
• Prognosis