Renal denervation decreases blood pressure in DOCA-treated miniature swine with established hypertension.

Abstract

The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation (RDX). During the first week post-RDX, MAP decreased from 141 /+- 6 to 121 +/- 3 mm Hg (P less than .05), while sodium balance increased from 0.32 +/- 0.05 to 0.95 +/- 0.14 mEq/kg/day (P less than .05). By 3 weeks post-RDX, MAP remained below normotensive levels while sodium balance returned to the pre-RDX value. There was no significant change in potassium or water balance after RDX. Thus, in DOCA-YMS the renal nerves are important in the maintenance of hypertension. The reduction in MAP with RDX in the absence of a natriuresis suggests a role for renal afferent nerve activity.

• Authors: K P O'Hagan, G D Thomas, E J Zambraski
• Journal: American journal of hypertension (Am J Hypertens) Vol. 3 Issue 1 Pg. 62-4 (Jan 1990) ISSN: 0895-7061 [Print] United States
• PMID: 2302330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Desoxycorticosterone
• Sodium

Topics

• Analysis of Variance
• Animals
• Blood Pressure (physiology)
• Desoxycorticosterone
• Female
• Hypertension (chemically induced, physiopathology)
• Kidney (innervation, surgery)
• Sodium (urine)
• Swine
• Swine, Miniature
• Sympathectomy