Evaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis.

Abstract

The aim of this study was to evaluate the cardiotoxic effects of pentavalent antimonial compounds in dogs with leishmaniasis. Twenty-eight dogs with clinical disease due to natural infection with Leishmania infantum were treated with 75 mg/kg meglumine antimoniate SC every 12h for 60 days. Serum cardiac troponin I (cTnI) concentrations were determined and routine and 24h ambulatory electrocardiographic monitoring was performed before the onset (T0) and at the end of treatment (T60). No abnormalities were found in routine and 24h electrocardiographic tracings before and after treatment. No statistical difference was found between serum cTnI concentrations or corrected QT intervals at T0 and T60. There was no evidence of laboratory or electrocardiographic features of cardiac toxicity in dogs with leishmaniasis treated with a therapeutic dose of meglumine antimoniate for 60 days.

• Authors: Alessia Luciani, Sarah Sconza, Carla Civitella, Carlo Guglielmini
• Journal: Veterinary journal (London, England : 1997) (Vet J) Vol. 196 Issue 1 Pg. 119-21 (Apr 2013) ISSN: 1532-2971 [Electronic] England
• PMID: 23021954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antiprotozoal Agents
• Organometallic Compounds
• Troponin I
• Meglumine
• Meglumine Antimoniate

Topics

• Animals
• Antiprotozoal Agents (adverse effects)
• Dog Diseases (drug therapy, metabolism)
• Dogs
• Electrocardiography (veterinary)
• Heart (drug effects)
• Leishmania infantum (physiology)
• Leishmaniasis, Visceral (drug therapy, metabolism, veterinary)
• Meglumine (adverse effects)
• Meglumine Antimoniate
• Organometallic Compounds (adverse effects)
• Prospective Studies
• Troponin I (blood)