Monostotic Langerhans' cell histiocytosis in a child with central diabetes insipidus.

Abstract

Langerhans'cell histiocytosis (LCH) comprises a rare group of reticuloendothelial system disorders that can produce focal or systemic manifestations. Diabetes insipidus is considered to be an important indicator of serious underlying diseases in children, including LCH. We report the case of a young patient with monostotic LCH confined to the mandibular ramus, who was diagnosed with the disease after presenting symptoms of central diabetes insipidus and was satisfactorily treated with multi-agent chemotherapy. Additionally, we discuss the clinical, radiographic, histological and immunohistochemical findings, as well as the multidisciplinary approach of this important disease, which should receive attention by dental practitioners, especially when it occurs in children.

• Authors: Eduardo Costa Studart Soares, Ana Rosa Pinto Quidute, Fábio Wildson Gurgel Costa, Maria Helane Costa Gurgel, Ana Paula Negreiros Nunes Alves, Cristiane Sá Roriz Fonteles
• Journal: The Journal of clinical pediatric dentistry (J Clin Pediatr Dent) Vol. 36 Issue 4 Pg. 377-81 ( 2012) ISSN: 1053-4628 [Print] United States
• PMID: 23019836 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antidiuretic Agents
• Cytostatic Agents
• Glucocorticoids
• Vinblastine
• Deamino Arginine Vasopressin
• Prednisone

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Antidiuretic Agents (therapeutic use)
• Child, Preschool
• Cytostatic Agents (therapeutic use)
• Deamino Arginine Vasopressin (therapeutic use)
• Diabetes Insipidus (diagnosis)
• Diagnosis, Differential
• Glucocorticoids (therapeutic use)
• Histiocytosis, Langerhans-Cell (diagnosis)
• Humans
• Male
• Mandibular Diseases (diagnosis)
• Prednisone (therapeutic use)
• Vinblastine (therapeutic use)