Synergistic enhancement of cancer therapy using a combination of fusion protein MG7-scFv/SEB and tumor necrosis factor alpha.

Abstract	The fusion protein MG7-scFv/SEB has shown anti-tumor activity on gastric cancer in vitro and in vivo. Tumor necrosis factor-alpha (TNF-α) is a cytokine exerting anti-tumor effectiveness in various models and modes of applications. In this study, we explored the combination effects of MG7-scFv/SEB and TNF-α in experimental gastric cancer. Both MG7-scFv/SEB and TNF-α could effectively result in a significant inhibition of tumor growth in our experimental models when administered alone. What's more, MG7-scFv/SEB synergized with TNF-α in further reducing the growth of gastric tumors in gastric-tumor-bearing rats as compared to mono therapy. Additionally, the survival rate of gastric-tumorbearing rats administrated with combined therapy was significantly higher than that of rats treated with MG7-scFv/SEB or TNF-α. These results indicate that combined therapy with MG7-scFv/SEB and TNF-α is a promising strategy for human cancer therapy.
Authors	Xiaoming Lu, Chao Cheng, Guobin Wang, Xiaogang Shu, Jingwei Ma, Qiang Tong
Journal	Protein and peptide letters (Protein Pept Lett) Vol. 20 Issue 4 Pg. 467-72 (Apr 2013) ISSN: 1875-5305 [Electronic] Netherlands
PMID	23016583 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Monoclonal Enterotoxins Immunoglobulin Fragments Recombinant Fusion Proteins Tumor Necrosis Factor-alpha enterotoxin B, staphylococcal
Topics	Animals Antibodies, Monoclonal (genetics) Antineoplastic Combined Chemotherapy Protocols (pharmacology) Cell Line, Tumor Drug Screening Assays, Antitumor Enterotoxins (genetics) Female Humans Immunoglobulin Fragments (genetics) Necrosis (chemically induced) Rats, Sprague-Dawley Recombinant Fusion Proteins (administration & dosage, genetics, pharmacology) Stomach Neoplasms (drug therapy, mortality) Tumor Necrosis Factor-alpha (administration & dosage, pharmacology)

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