[Biotransformation in vivo/vitro and bioactive properties of rare ginsenoside IH901].

Abstract

Recent metabolomics research revealed a new ginseng ginsenoside IH901 that is synthesized by intestinal microbial transformation in oral administration of ginseng. IH901 shows various biological activities, including anti-tumor, anti-inflammatory, anti-diabetic, and anti-aging. In recent years, great effort has been made to prepare IH901 by microbial and enzymatic transformation in a large scale. In this paper, we reviewed the biotransformation pathways both in vivo and in vitro and bioactive properties of rare ginsenoside IH901.

• Authors: Yuxing Tong, Zhizhong Zheng, Qingxuan Tong, Yi Lin, Yanlin Ming
• Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology (Sheng Wu Gong Cheng Xue Bao) Vol. 28 Issue 6 Pg. 684-95 (Jun 2012) ISSN: 1000-3061 [Print] China
• PMID: 23016305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol
• Ginsenosides
• Sapogenins

Topics

• Biotransformation
• Ginsenosides (metabolism, pharmacokinetics)
• Humans
• Intestinal Mucosa (metabolism)
• Intestines (microbiology)
• Panax (chemistry)
• Sapogenins (metabolism)