Melanoma tumor inhibition by tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations.

Abstract

Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(iv) complex, [PtCl(4)(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl(4)(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl(4)(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57Bl/6 mice without visible signs of nephrotoxicity.

• Authors: Danijela Maksimović-Ivanić, Sanja Mijatović, Ivana Mirkov, Stanislava Stošić-Grujičić, Djordje Miljković, Tibor J Sabo, Vladimir Trajković, Goran N Kaluđerović
• Journal: Metallomics : integrated biometal science (Metallomics) Vol. 4 Issue 11 Pg. 1155-9 (Nov 2012) ISSN: 1756-591X [Electronic] England
• PMID: 23014886 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV)
• Cisplatin

Topics

• Analysis of Variance
• Animals
• Antineoplastic Agents (pharmacology)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Cisplatin (pharmacology)
• Drug Screening Assays, Antitumor
• Melanoma, Experimental (drug therapy)
• Mice
• Mice, Inbred C57BL
• Organoplatinum Compounds (pharmacology, therapeutic use)