Abstract | AIM: The purpose of the study was to assess the comparison of 18F-FDG PET/CT and CT in patients with breast cancer (BC) already treated with primary therapy, in evaluating the diagnostic and prognostic values. METHODS: We retrospectively studied 190 patients (187 women and 3 men, mean age 61±11 years) with previous BC (all stages) after surgery and other primary treatments. They underwent within three months CT and 18F-FDG PET/CT examinations for the evaluation of disease status. Disease relapse was confirmed by clinical evaluation and/or radiological findings. Survival curves of disease-free survival (DFS) and overall survival (OS) were computed using Kaplan-Meier method. Cox analysis regression was used to determine predictive factors of DFS and OS. RESULTS: Of the overall 190 patients, 82 (43%) had evidence of clinical and/or imaging disease relapse, while 108 (57%) did not. Sensitivity, specificity, negative predictive and positive predictive values for disease relapse or progression were of 89% vs. 77%, 73% vs. 53%, 90% vs. 75% and 72% vs. 55%, respectively for PET/CT and CT. DFS curves were significantly different in patients with both negative and positive PET/CT and CT (log-rank test 33.6; P<0.0001 and 12.7; P=0.003, respectively). OS curves were similar in patients with positive/negative PET/CT and CT (P=NS). By both univariate and multivariate Cox regression analysis positive PET/CT was found to be related to the disease recurrence (HR 0.18 and 0.20, both P<0.0001, respectively). CONCLUSION: PET/CT is more accurate than CT in identification of disease relapse in a large population of BC patients. In women at high-risk of recurrence, PET/CT imaging can provide the early detection of BC metastases, tailoring a proper treatment.
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Authors | L Evangelista, Z Baretta, L Vinante, E Bezzon, V De Carolis, A R Cervino, M Gregianin, C Ghiotto, G Saladini, F Pomerri, P C Muzzio |
Journal | The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
(Q J Nucl Med Mol Imaging)
Vol. 56
Issue 4
Pg. 375-84
(Aug 2012)
ISSN: 1824-4785 [Print] Italy |
PMID | 23013667
(Publication Type: Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Breast Neoplasms
(diagnosis, epidemiology, therapy)
- Breast Neoplasms, Male
(diagnosis, epidemiology, therapy)
- Female
- Fluorodeoxyglucose F18
- Humans
- Italy
(epidemiology)
- Male
- Middle Aged
- Multimodal Imaging
(statistics & numerical data)
- Neoplasm Recurrence, Local
(diagnosis, epidemiology, prevention & control)
- Positron-Emission Tomography
- Prevalence
- Radiopharmaceuticals
- Reproducibility of Results
- Risk Factors
- Sensitivity and Specificity
- Tomography, X-Ray Computed
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