[Comparative evaluation of the hypnotic drugs under conditions of brain injury].

Abstract

The effect of hypnotic drugs on the brain stability with respect to complete ischemia posttraumatic convulsive reactions and hypoxia has been studied in animals with model brain injury. It is established that zopiclone exhibits pronounced hypnotic effect during the first and second week after brain injury, while nitrazepam, zolpidem, and melaxen are effective in the first week. The neuroprotective effects of zopiclone and zolpidem are more pronounced than those of melaxen and nitrazepam.

• Authors: Iu A Belozertsev, O A Shchelkanova, F Iu Belozertsev, S V Iuntsev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 8 Pg. 31-3 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23012993 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Azabicyclo Compounds
• Hypnotics and Sedatives
• Piperazines
• Pyridines
• zopiclone
• Zolpidem
• Nitrazepam

Topics

• Animals
• Azabicyclo Compounds (administration & dosage, therapeutic use)
• Brain Injuries (complications, drug therapy)
• Hypnotics and Sedatives (administration & dosage, therapeutic use)
• Hypoxia (complications, drug therapy)
• Injections, Intraperitoneal
• Mice
• Nitrazepam (administration & dosage, therapeutic use)
• Piperazines (administration & dosage, therapeutic use)
• Pyridines (administration & dosage, therapeutic use)
• Rats
• Respiration (drug effects)
• Seizures (complications, drug therapy)
• Sleep (drug effects)
• Sleep Initiation and Maintenance Disorders (drug therapy)
• Zolpidem