[Fullerene C60 exhibits immunomodulatory activity during adjuvant-induced arthritis in rats].

Abstract

The effect of fullerene C60 (FC60) on the immune processes during experimental adjuvant-induced arthritis (AA) in rats has been studied. The results indicate the inhibitory action of FN60 during AA on cellular splenocyte proliferation, neutrophil phagocytic and oxygen-stimulatory activities in the NBT test, and humoral immune mechanisms involved in the production of antinuclear antibodies, formation of circulating immune complexes, and restoration of morphological structure of spleen. Taken together, these results allow FC60 to be considered as a new potential pharmacological agent that can realize its effects mainly through anti-inflammatory and immunomodulatory activity.

• Authors: L É Vesnina, T V Mamontova, M V Mikitiuk, N A Bobrova, L A Kutsenko, G A Iaroshenko, I P Kaĭdashev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 8 Pg. 15-20 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23012990 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antibodies, Antinuclear
• Antigen-Antibody Complex
• Fullerenes
• Immunologic Factors
• Freund's Adjuvant
• fullerene C60

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Antibodies, Antinuclear (blood, immunology)
• Antigen-Antibody Complex (blood, immunology)
• Arthritis, Experimental (chemically induced, drug therapy, immunology)
• Cell Proliferation (drug effects)
• Cells, Cultured
• Freund's Adjuvant
• Fullerenes (administration & dosage, therapeutic use)
• Immunologic Factors (administration & dosage, therapeutic use)
• Lymphocytes (drug effects, immunology)
• Male
• Neutrophils (drug effects, immunology)
• Phagocytosis (drug effects)
• Rats
• Rats, Wistar
• Spleen (drug effects, immunology, pathology)