Abstract |
Hereby we present the synthesis of several ruthenium(II) and ruthenium(III) dithiocarbamato complexes. Proceeding from the Na[ trans-Ru(III)( dmso)(2)Cl(4)] (2) and cis-[Ru(II)( dmso)(4)Cl(2)] (3) precursors, the diamagnetic, mixed- ligand [Ru(II)L(2)( dmso)(2)] complexes 4 and 5, the paramagnetic, neutral [Ru(III)L(3)] monomers 6 and 7, the antiferromagnetically coupled ionic α-[Ru(III)(2)L(5)]Cl complexes 8 and 9 as well as the β-[Ru(III)(2)L(5)]Cl dinuclear species 10 and 11 (L = dimethyl- ( DMDT) and pyrrolidinedithiocarbamate ( PDT)) were obtained. All the compounds were fully characterised by elemental analysis as well as (1)H NMR and FTIR spectroscopy. Moreover, for the first time the crystal structures of the dinuclear β-[Ru(III)(2)( dmdt)(5)]BF(4)⋅CHCl(3)⋅CH(3)CN and of the novel [Ru(II)L(2)( dmso)(2)] complexes were also determined and discussed. For both the mono- and dinuclear Ru(II) and Ru(III) complexes the central metal atoms assume a distorted octahedral geometry. Furthermore, in vitro cytotoxicity of the complexes has been evaluated on non-small-cell lung cancer (NSCLC) NCI-H1975 cells. All the mono- and dinuclear Ru(III) dithiocarbamato compounds (i.e., complexes 6-10) show interesting cytotoxic activity, up to one order of magnitude higher with respect to cisplatin. Otherwise, no significant antiproliferative effect for either the precursors 2 and 3 or the Ru(II) complexes 4 and 5 has been observed.
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Authors | Eszter M Nagy, Andrea Pettenuzzo, Giulia Boscutti, Luciano Marchiò, Lisa Dalla Via, Dolores Fregona |
Journal | Chemistry (Weinheim an der Bergstrasse, Germany)
(Chemistry)
Vol. 18
Issue 45
Pg. 14464-72
(Nov 05 2012)
ISSN: 1521-3765 [Electronic] Germany |
PMID | 23012112
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antineoplastic Agents
- Coordination Complexes
- Organometallic Compounds
- dichlorotetrakis(dimethyl sulfoxide)ruthenium II
- Ruthenium
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Topics |
- Antineoplastic Agents
(chemistry, therapeutic use, toxicity)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Coordination Complexes
(chemistry, therapeutic use, toxicity)
- Crystallography, X-Ray
- Humans
- Lung Neoplasms
(drug therapy)
- Molecular Conformation
- Organometallic Compounds
(chemistry, therapeutic use, toxicity)
- Ruthenium
(chemistry)
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