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Chloramine-induced anaphylaxis while showering: a case report.

AbstractINTRODUCTION:
Sodium-N-chlorine-p-toluene sulfonamide, commonly known as chloramine-T, is a derivative of chlorine which is widely used as a disinfectant. For many years, chloramine-T has been described as a cause of immediate-type hypersensitivity, especially with regard to asthma and rhinitis, and as a cause of occupational dermatoses in cleaning personnel in hospitals, although no anaphylactic reaction has yet been reported. Hence, to the best of our knowledge we present the first case of anaphylaxis to chloramine-T with evidence of specific immunoglobulin E antibodies.
CASE PRESENTATION:
We describe the case of a 25-year-old Caucasian woman who was in good health and with a negative history for atopy, including no respiratory symptoms of rhinitis or asthma, and with no professional exposure to chloramine-T. She, while showering, applied a chloramine-T solution to a skin area with folliculitis on her leg, and within a few minutes developed generalized urticaria and angioedema, followed by vomiting and collapse with loss of consciousness. A skin prick test with a chloramine-T solution at 10mg/mL concentration was positive, and specific immunoglobulin E to chloramine-T was quantified at a value of 2.9 optical density as measured by the enzyme allergosorbent test technique.
CONCLUSION:
The strict cause-effect relationship and the results of the skin test and the in vitro test make certain the causative role of chloramine-T in this case of anaphylaxis. This suggests that chloramine-T, based on its wide use as a disinfectant, should be considered a possible cause in anaphylaxis of unknown origin.
AuthorsSimona D'Alò, Tiziana De Pasquale, Cristoforo Incorvaia, Ilenia Illuminati, Gianni Mistrello, Daniela Roncarolo, Stefano Pucci
JournalJournal of medical case reports (J Med Case Rep) Vol. 6 Pg. 324 (Sep 25 2012) ISSN: 1752-1947 [Electronic] England
PMID23009577 (Publication Type: Journal Article)

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