Identification of fructose 3-phosphate in the lens of diabetic rats.

Abstract

Fructose 3-phosphate, a novel monosaccharide phosphate, has been identified in the lens of diabetic rats. This compound, which is not present in normal lenses, is a protein glycosylating agent and enzyme inactivator. In addition, because of its structural features, this metabolite is relatively labile and undergoes hydrolysis to yield inorganic phosphate and the potent glycosylating agent, 3-deoxyglucosone. The increase in the concentration of fructose 3-phosphate in the lens of diabetic rats suggests that it and its hydrolysis product, 3-deoxyglucosone, may be responsible in part for the development of some diabetic complications in the lens.

• Authors: B S Szwergold, F Kappler, T R Brown
• Journal: Science (New York, N.Y.) (Science) Vol. 247 Issue 4941 Pg. 451-4 (Jan 26 1990) ISSN: 0036-8075 [Print] United States
• PMID: 2300805 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cross-Linking Reagents
• Fructosephosphates
• fructose 3-phosphate
• Deoxyglucose
• L-Lactate Dehydrogenase
• Fructose-Bisphosphate Aldolase
• 3-deoxyglucosone

Topics

• Animals
• Cross-Linking Reagents
• Deoxyglucose (analogs & derivatives, metabolism, pharmacology)
• Diabetes Mellitus, Experimental (metabolism)
• Fructose-Bisphosphate Aldolase (antagonists & inhibitors)
• Fructosephosphates (analysis, metabolism, pharmacology)
• Glycosylation
• Hydrolysis
• L-Lactate Dehydrogenase (antagonists & inhibitors)
• Lens, Crystalline (metabolism)
• Magnetic Resonance Spectroscopy
• Rats