[Study on effects of kurarinol combined with glycyrrhizic acid on cellular immunity of patients with chronic hepatitis B].

Abstract

OBJECTIVE:

To explore effects of kurarinol combined with Diammonium Glycyrrhizinate on specific cellular immunity of patients with chronic hepatitis B (CHB).

METHODS:

Sixty-three CHB patients were randomly divided into two groups, 32 cases in group of kurarinol combined with Diammonium Glycyrrhizinate group (combined therapy group) were treated with 600 mg kurarinol glucose injection intravenously, once a day for one month, then 200 mg kurarinol capsule was used orally, three times a day for two months. 150 mg Diammonium Glycyrrhizinate for Injection was added to 250 ml 10% glucose injection for intravenous drip, once a day for one month, then 150 mg Diammonium Glycyrrhizinate capsule was used orally, three times a day for two months; 31 case in kurarinol group (single drug group) only used kurarinol, methods and dosage were the same as those of treatment group. HBV specific CTL, T cell subgroups, change of Th1 and Th2 level, HBV-DNA and HBeAg negative rate of the two groups were compared.

RESULTS:

Three months after treatment, HBV specific CTL, CD4 + and Th1 of combined therapy group were higher than those before treatment, and higher than those of single drug group after treatment (P < 0.01).

CONCLUSION:

HBV-DNA and HBeAg negative rate between the two groups had no statistic significance (P > 0.05).

CONCLUSION:

Kurarinol combined with Diammonium Glycyrrhizinate can further increase HBV specific CTL, CD4+ and Th1 level of CHB patients.

• Authors: Xi-Bing Gu, Xiao-Juan Yang, Xiang-Hu Jiang, Zhong Hua, Zhong-Hua Lu, Bo Zhang, Yin-Fang Zhu, Hang-Yuan Wu, Yi-Ming Jiang, Hao-Kun Chen, Hao Pei, Yu-Lin Zhou
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 26 Issue 2 Pg. 108-10 (Apr 2012) ISSN: 1003-9279 [Print] China
• PMID: 23002547 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• DNA, Viral
• Flavonoids
• Hepatitis B e Antigens
• kurarinol
• Glycyrrhizic Acid

Topics

• Adult
• DNA, Viral (analysis)
• Drug Therapy, Combination
• Female
• Flavonoids (administration & dosage)
• Glycyrrhizic Acid (administration & dosage)
• Hepatitis B e Antigens (analysis)
• Hepatitis B, Chronic (drug therapy, immunology, virology)
• Humans
• Immunity, Cellular (drug effects)
• Male
• Middle Aged