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Effect of resinous extract from Commiphora swynnertonii (Burrt) on experimental coccidial infection in chickens.

Abstract
A crude resinous extract from Commiphora swynnertonii was tested against an experimental coccidial infection in local chickens. A total of 80 growing chickens were randomly assigned into five groups, which received different treatments. Chickens in G1 were not infected with coccidian oocysts and therefore served as a negative control. All chickens in G2, G3, G4 and G5 were infected through oral administration of coccidian oocysts suspension at a dosed rate of 1.5 × 10(4) Eimeria spp. oocysts per bird. Starting from day 3 post-infection (p.i), chickens in different groups were treated for 7 consecutive days as follows: G1 and G2 (positive control) received 5 ml of normal saline as placebo, G3 and G4 were given the extract at 400 and 800 mg/kg bodyweight whereas G5 received anticoccidial drug. Clinical signs, bodyweights, oocysts counts and mortality rates were observed regularly. Results showed that oral administration of the resinous extract to chickens with coccidiosis significantly reduced mortality rate from 94 to 25 % and oocysts counts from 1.03 × 10(5) to 6.55 × 10(3) oocysts/g faeces (p < 0.05). Also a body condition score chart indicated less severe clinical signs of the disease in the groups which received the extract. Mean daily body weights were slightly reduced by the administration of the extract but this effect disappeared by day 7 p.i. These findings clearly indicate that resinous extract from C. swynnertonii has significant anticoccidial effect against experimental Eimeria spp. infection in chickens. A larger field trial to validate the use of the extract in chickens naturally infected with Eimeria spp. is required.
AuthorsGaymary G Bakari, Robert A Max, Robinson H Mdegela, Elliot C J Phiri, Mkumbukwa M A Mtambo
JournalTropical animal health and production (Trop Anim Health Prod) Vol. 45 Issue 2 Pg. 455-9 (Feb 2013) ISSN: 1573-7438 [Electronic] United States
PMID23001540 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Protozoan
  • Coccidiostats
  • Resins, Plant
Topics
  • Animals
  • Antibodies, Protozoan (blood)
  • Chickens
  • Coccidiosis (drug therapy, virology)
  • Coccidiostats (therapeutic use)
  • Commiphora (chemistry)
  • Eimeria (drug effects, immunology)
  • Parasite Egg Count (veterinary)
  • Plant Structures (chemistry)
  • Poultry Diseases (drug therapy, virology)
  • Resins, Plant (therapeutic use)

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