Sulphadiazine-induced renal stones in a 63-year-old HIV-infected man treated for toxoplasmosis.

Abstract

A 63-year-old man was admitted for investigation of blurred vision and multiple ring-enhancing lesions on cranial MRI. Histopathological examination of tissue obtained at brain biopsy showed multiple Toxoplasma gondii cysts. He was started on a combination of sulphadiazine and pyrimethamine for cerebral toxoplasmosis and was subsequently diagnosed with HIV-1 infection. He then developed acute renal failure and flank pain and was diagnosed with bilateral vesico-uretric calculi requiring bilateral stent insertion. The retrieved renal calculi were negative for the common stones that are routinely tested for in our laboratory and had the macroscopic characteristics of a sulphadiazine stone. His renal failure responded to cessation of the sulphadiazine.

• Authors: Benjamin David McGettigan, Meilyn Hew, Elizabeth Phillips, Andrew McLean-Tooke
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2012 (Sep 21 2012) ISSN: 1757-790X [Electronic] England
• PMID: 23001098 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiprotozoal Agents
• Sulfadiazine

Topics

• AIDS-Related Opportunistic Infections (diagnosis, drug therapy)
• Antiprotozoal Agents (adverse effects, therapeutic use)
• Diagnosis, Differential
• HIV-1
• Humans
• Kidney Calculi (chemically induced)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neuroimaging
• Sulfadiazine (adverse effects, therapeutic use)
• Toxoplasmosis, Cerebral (diagnosis, drug therapy)