Reducing the concentration to 0.4% enantiomeric excess hyperbaric levobupivacaine (s75: r25) provides unilateral spinal anesthesia. Study with different volumes.

Abstract

BACKGROUND AND OBJECTIVES:

Unilateral spinal anesthesia may be obtained with hypobaric or hyperbaric solution. The objective of this study was to compare different doses of enantiomeric excess hyperbaric levobupivacaine to achieve unilateral spinal anesthesia.

METHOD:

One hundred and twenty patients were randomized to receive 4 mg, 6 mg or 8 mg of 0.4% enantiomeric excess levobupivacaine. The solutions were administered at the L3-L4, with the patient in a lateral position and kept at this position according to dose administration for 5, 10 or 15 minutes. Sensory block (pinprick) and motor block (scale 0-3) were compared between the operated and contralateral sides.

RESULTS:

The onset of analgesia was rapid and comparable between groups. Sensory block was significantly higher in the operated than in nonoperated limb at all times of evaluation. Increasing the dose by 1 mL (2mg) corresponded to an increase of two segments in the mode for the operated side. In the operated side, motor block (MB = 3) of patients occurred in 31 (77.5%) with 4 mg, 38 (95%) with 6 mg, and 40 (100%) with 8 mg. There was a positive correlation between increased dose, blockade duration, and hypotension. All patients were satisfied with the technique used.

CONCLUSIONS:

Spinal anesthesia with different volumes of enantiomeric excess hyperbaric bupivacaine (S75: R25) provided a 78% incidence of unilateral spinal block, with the smallest dose used (4 mg) the most efficient.

• Authors: Luiz Eduardo Imbelloni, Marildo A Gouveia, Antonio Fernando Carneiro, Renata Grigorio
• Journal: Revista brasileira de anestesiologia (Rev Bras Anestesiol) 2012 Sep-Oct Vol. 62 Issue 5 Pg. 654-64 ISSN: 1806-907X [Electronic] Brazil
• PMID: 22999398 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2012 Elsevier Editora Ltda. All rights reserved.

Chemical References

• Anesthetics, Local
• Levobupivacaine
• Bupivacaine

Topics

• Adult
• Anesthesia, Spinal (methods)
• Anesthetics, Local (administration & dosage, chemistry)
• Bupivacaine (administration & dosage, analogs & derivatives, chemistry)
• Female
• Humans
• Levobupivacaine
• Male
• Prospective Studies
• Single-Blind Method