Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.

Abstract

Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.

• Authors: Anna A Shvedova, Alexey V Tkach, Elena R Kisin, Timur Khaliullin, Shyla Stanley, Dmitriy W Gutkin, Alexander Star, Yanan Chen, Galina V Shurin, Valerian E Kagan, Michael R Shurin
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 9 Issue 9-10 Pg. 1691-5 (May 27 2013) ISSN: 1613-6829 [Electronic] Germany
• PMID: 22996965 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Nanotubes, Carbon

Topics

• Animals
• Bone Marrow Cells (pathology)
• Cell Division
• Female
• Lung Neoplasms (metabolism, pathology)
• Mice
• Mice, Inbred C57BL
• Nanotubes, Carbon
• Up-Regulation