Failure of surgery and isotretinoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva: report of two cases.

Two patients with fibrodysplasia ossificans progressiva who presented with jaw immobilization due to formation of bone between the maxilla and mandible were treated with surgical resection of their ectopic bone in conjunction with experimental, adjunctive medical therapy using isotretinoin. Both patients had recurrence of their ectopic ossification within 2 months of surgery. Surgery to remove joint-bridging ossifications in FOP is not recommended.
AuthorsL J Crofford, J S Brahim, M A Zasloff, J C Marini
JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 48 Issue 2 Pg. 204-8 (Feb 1990) ISSN: 0278-2391 [Print] UNITED STATES
PMID2299462 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Isotretinoin
  • Adolescent
  • Child, Preschool
  • Humans
  • Isotretinoin (therapeutic use)
  • Jaw Diseases (drug therapy, surgery)
  • Male
  • Myositis Ossificans (drug therapy, surgery)
  • Recurrence

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