Organ donation: when should we consider intestinal donation.

Abstract

UNLABELLED:

Although more than 2300 intestinal transplantations (IT) have been performed worldwide, a description of intestinal donor criteria is still missing. This causes confusion among transplant coordinators, OPOs, physicians at intensive care unit and transplant surgeons. A Med-line search looking for publications about donor criteria or donor selection in human IT was performed in December 2011. Retrospective analysis of 39 deceased donors from whom, in the period January 2006-December 2011, 20 isolated intestinal grafts and 19 multivisceral grafts were recovered and successfully transplanted.

REVIEW OF THE LITERATURE:

Among 3504 publications about IT, no study reported specifically about intestinal donor profile. The most commonly cited donor criterion was age, while all other criteria were inconsistently discussed. Based on the collected data, we suggest following inclusion criteria for donation of IT grafts: age 0-50 years, ICU-stay <1 week, no blunt abdominal trauma, most recent Sodium <155 mmol/l, no severe ongoing transfusion requirements, standard donor therapy including early enteral nutrition and a compatible donor-recipient size match. By providing simple criteria for intestinal donation from deceased donor, we may help to properly utilize the limited donor pool.

• Authors: Carl-Ludwig Fischer-Fröhlich, Alfred Königsrainer, Randolph Schaffer, Franz Schaub, Johann Pratschke, Andreas Pascher, Wolfgang Steurer, Silvio Nadalin
• Journal: Transplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 25 Issue 12 Pg. 1229-40 (Dec 2012) ISSN: 1432-2277 [Electronic] Switzerland
• PMID: 22994541 (Publication Type: Journal Article, Review)
• Copyright: © 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.

Chemical References

• Organ Preservation Solutions

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Donor Selection
• Graft Survival
• Humans
• Infant
• Intestines (transplantation)
• Middle Aged
• Organ Preservation Solutions
• Retrospective Studies
• Tissue Donors
• Tissue and Organ Procurement (standards)
• Treatment Outcome