Exposure-response relationships in asthma caused by tetrachlorophthalic anhydride.

Abstract

Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels of TCPA exposure. Measurements of TCPA in the test-cubicle air ranged from 1.3 to 961.1 micrograms/m3. The higher exposures provoked definite late or dual asthmatic responses. Smaller, but statistically significant, responses were observed at low exposures. The late asthmatic-response area had a linear relation to the logarithm of TCPA exposure, but the immediate asthmatic response was less closely related to exposure.

• Authors: K M Venables, A J Newman Taylor
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 85 Issue 1 Pt 1 Pg. 55-8 (Jan 1990) ISSN: 0091-6749 [Print] United States
• PMID: 2299106 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Air Pollutants, Occupational
• Dust
• Phthalic Acids
• Phthalic Anhydrides
• tetrachlorophthalic anhydride
• Histamine

Topics

• Adult
• Air Pollutants, Occupational (adverse effects, analysis)
• Asthma (chemically induced, diagnosis)
• Bronchial Provocation Tests (methods)
• Dose-Response Relationship, Drug
• Dust (adverse effects)
• Female
• Forced Expiratory Volume (drug effects)
• Histamine
• Humans
• Middle Aged
• Occupational Diseases (chemically induced, diagnosis)
• Phthalic Acids (adverse effects)
• Phthalic Anhydrides (adverse effects, analysis)
• Skin Tests