Abstract | BACKGROUND: A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of the peripheral and central insulin receptors. Recently, dicholine succinate, a sensitizer of the neuronal insulin receptor, was shown to stimulate insulin-dependent H2O2 production of the mitochondrial respiratory chain leading to an enhancement of insulin receptor autophosphorylation in neurons. As such, this mechanism can be a novel target for the elevation of insulin signaling. RESULTS: Administration of DS (25 mg/kg/day, intraperitoneal) in CD1 mice for 7 days prior to the onset of stress procedure, diminished manifestations of anhedonia defined in a sucrose test and behavioral despair in the forced swim test. Treatment with dicholine succinate reduced the anxiety scores of stressed mice in the dark/light box paradigm, precluded stress-induced decreases of long-term contextual memory in the step-down avoidance test and hippocampal gene expression of IGF2. CONCLUSIONS:
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Authors | Brandon H Cline, Harry W M Steinbusch, Dmitry Malin, Alexander V Revishchin, Galia V Pavlova, Raymond Cespuglio, Tatyana Strekalova |
Journal | BMC neuroscience
(BMC Neurosci)
Vol. 13
Pg. 110
(Sep 18 2012)
ISSN: 1471-2202 [Electronic] England |
PMID | 22989159
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents
- IGF2 protein, mouse
- Insulin-Like Growth Factor II
- Receptor, Insulin
- Succinylcholine
- Imipramine
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Topics |
- Animals
- Antidepressive Agents
(pharmacology, therapeutic use)
- Anxiety
(complications, drug therapy, psychology)
- Depression
(complications, drug therapy, psychology)
- Disease Models, Animal
- Hippocampus
(drug effects, metabolism)
- Imipramine
(pharmacology, therapeutic use)
- Insulin-Like Growth Factor II
(biosynthesis, physiology)
- Male
- Memory Disorders
(complications, drug therapy, psychology)
- Mice
- Mice, Inbred ICR
- Neurons
(metabolism)
- Receptor, Insulin
(metabolism)
- Stress, Psychological
(complications, drug therapy, psychology)
- Succinylcholine
(pharmacology, therapeutic use)
- Up-Regulation
(drug effects)
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