Abstract |
Protein- tyrosine phosphorylation, which is catalyzed by protein-tyrosine kinase (PTK), plays a pivotal role in a variety of cellular functions related to health and disease. The discovery of the viral oncogene Src (v-Src) and its cellular nontransforming counterpart (c-Src), as the first example of PTK, has opened a window to study the relationship between protein- tyrosine phosphorylation and the biology and medicine of cancer. In this paper, we focus on the roles played by Src and other PTKs in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i.e., hypoxia, anoikis, hypoglycemia, and serum deprivation).
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Authors | A K M Mahbub Hasan, Takashi Ijiri, Ken-Ichi Sato |
Journal | Journal of signal transduction
(J Signal Transduct)
Vol. 2012
Pg. 483796
( 2012)
ISSN: 2090-1747 [Electronic] United States |
PMID | 22988500
(Publication Type: Journal Article)
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