Triptolide inhibits amyloid-β production and protects neural cells by inhibiting CXCR2 activity.

Abstract

Triptolide, a biologically active natural product from Tripterygium wilfordii, protects neurons from inflammation-mediated damage. Our results showed for the first time that triptolide inhibited the expression of CXCR2 and presenilin in a neuroblastoma cell line SHSY5Ysw. Moreover, triptolide potently inhibited amyloid-β1-42 production with IC50 value of 30 pM in HEK293sw cells or 2 nM in SHSY5Ysw cells, respectively. We also demonstrated that triptolide prevented primary cortical neurons from chemokine CXCL1-induced cytotoxicity. Therefore, our study indicates that the neural protective effect of triptolide is largely mediated by inhibiting CXCR2 activity.

• Authors: Ju Wang, Zi-Qi Shi, Xiaojun Xu, Gui-Zhong Xin, Jun Chen, Lian-Wen Qi, Ping Li
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 33 Issue 1 Pg. 217-29 ( 2013) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 22986777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Diterpenes
• Epoxy Compounds
• Neuroprotective Agents
• Peptide Fragments
• Phenanthrenes
• Receptors, Interleukin-8B
• amyloid beta-protein (1-42)
• triptolide

Topics

• Amyloid beta-Peptides (antagonists & inhibitors, biosynthesis)
• Animals
• Cell Line, Tumor
• Cells, Cultured
• Diterpenes (pharmacology)
• Dose-Response Relationship, Drug
• Epoxy Compounds (pharmacology)
• HEK293 Cells
• Humans
• Neurons (drug effects, metabolism)
• Neuroprotective Agents (pharmacology)
• Peptide Fragments (antagonists & inhibitors, biosynthesis)
• Phenanthrenes (pharmacology)
• Rats
• Receptors, Interleukin-8B (antagonists & inhibitors, metabolism)
• Tripterygium