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Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats.

Abstract
Naringin, a well-known flavanone glycoside of grapefruit and citrus fruits, was found to be as an effective anti-inflammatory compound in our previous lipopolysaccharide-induced acute lung injury mouse model via blockading activity of nuclear factor κB. The current study sought to explore the anti-inflammatory effects of naringin on chronic pulmonary neutrophilic inflammation in cigarette smoke (CS)-induced rats. Seventy Sprague-Dawley rats were randomly divided into seven groups to study the effects of CS with or without various concentrations of naringin or saline for 8 weeks. The results revealed that naringin supplementation at 20, 40, and 80 mg/kg significantly increased body weight of CS-induced rats as compared to that in the CS group. Moreover, naringin of 20, 40, and 80 mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-α and interleukin-8 (IL-8). IL-10 in bronchoalveolar lavage fluid was significantly suppressed after CS exposure, but dose dependently elevated by naringin. The results from hematoxylin and eosin staining revealed that naringin dose dependently reduced CS-induced infiltration of inflammatory cells, thickening of the bronchial wall, and expansion of average alveolar airspace. In conclusion, our data suggest that naringin is an effective anti-inflammatory compound for attenuating chronic pulmonary neutrophilic inflammation in CS-induced rats.
AuthorsYi-Chu Nie, Hao Wu, Pei-Bo Li, Yu-Long Luo, Kang Long, Li-Ming Xie, Jian-Gang Shen, Wei-Wei Su
JournalJournal of medicinal food (J Med Food) Vol. 15 Issue 10 Pg. 894-900 (Oct 2012) ISSN: 1557-7600 [Electronic] United States
PMID22985397 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Flavanones
  • Interleukin-8
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Peroxidase
  • Matrix Metalloproteinase 9
  • Mmp9 protein, rat
  • naringin
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Bronchoalveolar Lavage Fluid (chemistry)
  • Female
  • Flavanones (pharmacology)
  • Interleukin-10 (antagonists & inhibitors, metabolism)
  • Interleukin-8 (antagonists & inhibitors, metabolism)
  • Male
  • Matrix Metalloproteinase 9 (genetics, metabolism)
  • Neutrophils (drug effects, pathology)
  • Peroxidase (genetics, metabolism)
  • Pneumonia (drug therapy, pathology)
  • Pulmonary Disease, Chronic Obstructive (drug therapy, pathology)
  • Rats
  • Rats, Sprague-Dawley
  • Smoking (adverse effects)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors, metabolism)

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