Abstract |
Naringin, a well-known flavanone glycoside of grapefruit and citrus fruits, was found to be as an effective anti-inflammatory compound in our previous lipopolysaccharide-induced acute lung injury mouse model via blockading activity of nuclear factor κB. The current study sought to explore the anti-inflammatory effects of naringin on chronic pulmonary neutrophilic inflammation in cigarette smoke (CS)-induced rats. Seventy Sprague-Dawley rats were randomly divided into seven groups to study the effects of CS with or without various concentrations of naringin or saline for 8 weeks. The results revealed that naringin supplementation at 20, 40, and 80 mg/kg significantly increased body weight of CS-induced rats as compared to that in the CS group. Moreover, naringin of 20, 40, and 80 mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-α and interleukin-8 (IL-8). IL-10 in bronchoalveolar lavage fluid was significantly suppressed after CS exposure, but dose dependently elevated by naringin. The results from hematoxylin and eosin staining revealed that naringin dose dependently reduced CS-induced infiltration of inflammatory cells, thickening of the bronchial wall, and expansion of average alveolar airspace. In conclusion, our data suggest that naringin is an effective anti-inflammatory compound for attenuating chronic pulmonary neutrophilic inflammation in CS-induced rats.
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Authors | Yi-Chu Nie, Hao Wu, Pei-Bo Li, Yu-Long Luo, Kang Long, Li-Ming Xie, Jian-Gang Shen, Wei-Wei Su |
Journal | Journal of medicinal food
(J Med Food)
Vol. 15
Issue 10
Pg. 894-900
(Oct 2012)
ISSN: 1557-7600 [Electronic] United States |
PMID | 22985397
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Flavanones
- Interleukin-8
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Peroxidase
- Matrix Metalloproteinase 9
- Mmp9 protein, rat
- naringin
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Female
- Flavanones
(pharmacology)
- Interleukin-10
(antagonists & inhibitors, metabolism)
- Interleukin-8
(antagonists & inhibitors, metabolism)
- Male
- Matrix Metalloproteinase 9
(genetics, metabolism)
- Neutrophils
(drug effects, pathology)
- Peroxidase
(genetics, metabolism)
- Pneumonia
(drug therapy, pathology)
- Pulmonary Disease, Chronic Obstructive
(drug therapy, pathology)
- Rats
- Rats, Sprague-Dawley
- Smoking
(adverse effects)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, metabolism)
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