Danger of hypoglycemia due to acute tramadol poisoning.

Abstract

OBJECTIVE:

To report a case of prolonged hypoglycemia after acute tramadol poisoning.

METHODS:

We describe a patient's clinical presentation and outcome with prolonged hypoglycemia attributable to acute tramadol poisoning. In addition, the possible mechanism for the hypoglycemia is discussed, and a brief review of the pertinent literature is presented.

RESULTS:

A 54-year-old woman had previously undergone a partial hepatectomy because of involvement of her liver by a gastrointestinal stromal tumor. After ingestion of 3,000 mg of tramadol with suicidal intent, she developed prolonged hypoglycemia that necessitated treatment with continuous intravenous glucose infusion for 24 hours. Reports in the literature have described central nervous system depression, nausea, vomiting, tachycardia, seizures, and even death from tramadol overdoses.

CONCLUSION:

This report alerts clinicians to the potential danger of severe hypoglycemia in tramadol poisoning.

• Authors: Nadarajah Mugunthan, Peter Davoren
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) 2012 Nov-Dec Vol. 18 Issue 6 Pg. e151-2 ISSN: 1934-2403 [Electronic] United States
• PMID: 22982791 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Analgesics, Opioid
• Tramadol
• Glucose

Topics

• Analgesics, Opioid (poisoning)
• Female
• Gastrointestinal Neoplasms (pathology)
• Gastrointestinal Stromal Tumors (secondary, surgery)
• Glucose (administration & dosage, therapeutic use)
• Hepatectomy
• Humans
• Hypoglycemia (chemically induced, drug therapy, epidemiology)
• Infusions, Intravenous
• Liver Neoplasms (secondary, surgery)
• Middle Aged
• Risk Factors
• Suicide, Attempted
• Tramadol (poisoning)
• Treatment Outcome