Phosphaturic mesenchymal tumor: a report of 6 patients treated at a single institution and comparison with reported series.
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| Abstract |
Osteogenic osteomalacia (OO)-associated phosphaturic mesenchymal tumors (PMTs) might represent a single histopathologic paraneoplastic entity. These tumors are largely misunderstood, ignored, or unknown by pathologists and clinicians. To elucidate the characteristics of OO-associated PMTs, we retrospectively analyzed the clinicopathologic features of PMTs from 6 patients, with either known OO or features suggestive of PMT-mixed connective tissue variant, who were studied and managed at a single center during the period from 1993 to 2011. Histologically, the tumor showed proliferation of spindle cells with focal areas of matrix production that showed distinct calcification, ossification, and osteoid-like matrix. Two patients had no evidence of disease and normal biochemical values; the other 2 patients each had multiple surgeries for multiple recurrences. In conclusion, PMT is histologically a benign lesion, with the malignant and metastatic variant being extremely rare. Infiltration of surrounding tissue is a frequent feature that is best managed with complete surgical removal of all involved tissue, which dramatically resolves the tumor-associated osteomalacia.
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| Authors | Hanadi A Fatani, Mohamad Sunbuli, Stephen Y Lai, Diana Bell |
| Journal | Annals of diagnostic pathology (Ann Diagn Pathol) Vol. 17 Issue 4 Pg. 319-21 (Aug 2013) ISSN: 1532-8198 [Electronic] United States |
| PMID | 22981782 (Publication Type: Journal Article) |
| Copyright | Published by Elsevier Inc. |
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