23(S),25(R)-1,25-dihydroxyvitamin D3-26,23-lactone stimulates murine bone formation in vivo.

Abstract

23(S),25(R)-1,25-Dihydroxyvitamin D3-26,23-lactone (1,25-lactone) has been shown to have unique actions different from those of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. In contrast to 1,25-(OH)2D3, 1,25-lactone causes a significant reduction in the serum Ca2+ level, stimulates collagen production in an osteoblastic cell line, and inhibits bone resorption induced by 1,25-(OH)2D3. A possible effect of 1,25-lactone on bone formation was examined in experiments on ectopic bone formation using a bone-inducing factor derived from Dunn osteosarcomas. 1,25-Lactone, a metabolite of 1,25-(OH)2D3, increased [3H]proline uptake at the stage of chondrogenesis and 85Sr uptake during bone formation. Significantly enlarged bone was also induced by this compound 3 weeks after implantation. These results suggest that the 1,25-lactone may be able to stimulate bone formation under in vivo conditions.

• Authors: M Shima, H Tanaka, A W Norman, K Yamaoka, H Yoshikawa, K Takaoka, S Ishizuka, Y Seino
• Journal: Endocrinology (Endocrinology) Vol. 126 Issue 2 Pg. 832-6 (Feb 1990) ISSN: 0013-7227 [Print] United States
• PMID: 2298173 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Strontium Radioisotopes
• Phosphorus
• 1,25-dihydroxyvitamin D3-26,23-lactone
• Collagen
• Proline
• Calcitriol
• Calcium

Topics

• Animals
• Bone Development (drug effects)
• Calcitriol (administration & dosage, analogs & derivatives, pharmacology)
• Calcium (blood)
• Collagen (biosynthesis)
• Male
• Mice
• Osteoblasts (drug effects, metabolism)
• Phosphorus (blood)
• Proline (metabolism)
• Strontium Radioisotopes (metabolism)