Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response.

Abstract

We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.

• Authors: A A Ligacheva, A N Ivanova, Yu P Belsky, N V Belska, E S Trofimova, M G Danilets, A M Dygai
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 4 Pg. 472-4 (Aug 2012) ISSN: 1573-8221 [Electronic] United States
• PMID: 22977847 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytokines
• NF-kappa B
• Gold Sodium Thiomalate
• Diclofenac
• Ovalbumin

Topics

• Analysis of Variance
• Animals
• Cytokines (immunology)
• Diclofenac (pharmacology, therapeutic use)
• Erythrocytes
• Female
• Gold Sodium Thiomalate (pharmacology, therapeutic use)
• Hypersensitivity, Delayed (chemically induced, drug therapy)
• Hypersensitivity, Immediate (chemically induced, drug therapy)
• Immunity, Cellular (immunology)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• NF-kappa B (antagonists & inhibitors)
• Ovalbumin (toxicity)
• Th1 Cells (immunology)
• Th2 Cells (immunology)