IgG4-associated tubulointerstitial nephritis: two case reports and a literature review.

Abstract

IgG4-related systemic disease (IgG4-RSD) is an autoimmune disease that includes a wide variety of lesions. IgG4-RSD is characterized by high levels of serum IgG4, abundant levels of IgG4-positive plasma cells and T-lymphocyte infiltration in various organs. Tubulointerstitial nephritis (TIN) is a major finding when the kidneys are involved and is effectively treated with corticosteroid therapy. We herein describe two cases of IgG4-related TIN. Such cases have rarely been reported in China.

• Authors: Yi Fang, Jun Hou, Fengqing Cai, Xiaoqiang Ding, Hong Liu
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 17 Pg. 2385-91 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 22975554 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulin G

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Aged
• Autoimmune Diseases (diagnosis, drug therapy, immunology)
• Cell Movement
• China
• Humans
• Immunoglobulin G (metabolism)
• Kidney (pathology)
• Male
• Middle Aged
• Nephritis, Interstitial (diagnosis, drug therapy, immunology)
• T-Lymphocytes (pathology)
• Treatment Outcome