Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: MATERIALS AND METHODS: RESULTS: The results showed a significant inhibition of proliferation in E. purpurea flower extract and cichoric acid in a dose- and time-dependent manner. Cichoric acid treatment decreased telomerase activity in HCT-116 cells. Moreover, cichoric acid effectively induced apoptosis in colon cancer cells, which were characterized by DNA fragmentation, activation of caspase-9, cleavage of PARP and downregulation of β- catenin. CONCLUSIONS: Our data indicate that cichoric acid has a strong growth-inhibitory effect against colon cancer cells, presumably resulting from the reduced telomerase activity and the induction of apoptosis. The exact mechanism of action should still be determined in future studies. Overall, the effects of 50% aqueous ethanol extract of E. purpurea flowers and cichoric acid may have provided in vitro evidence for the use as chemotherapeutic agents.
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Authors | Yu-Ling Tsai, Chien-Chih Chiu, Jeff Yi-Fu Chen, Kung-Chi Chan, Sheng-Dun Lin |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 143
Issue 3
Pg. 914-9
(Oct 11 2012)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 22971663
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Caffeic Acids
- Plant Extracts
- Succinates
- beta Catenin
- Poly(ADP-ribose) Polymerases
- Telomerase
- Caspase 9
- chicoric acid
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Topics |
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Caco-2 Cells
- Caffeic Acids
(pharmacology)
- Caspase 9
(metabolism)
- Cell Survival
(drug effects)
- Colonic Neoplasms
- DNA Fragmentation
- Echinacea
- Flowers
- HCT116 Cells
- Humans
- Plant Extracts
(pharmacology)
- Poly(ADP-ribose) Polymerases
(metabolism)
- Succinates
(pharmacology)
- Telomerase
(metabolism)
- beta Catenin
(metabolism)
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