Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers.

Abstract

AIM:

To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers.

METHODS:

We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, and for mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system.

RESULTS:

MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates.

CONCLUSION:

Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.

• Authors: Doron Boltin, Marisa Halpern, Zohar Levi, Alex Vilkin, Sara Morgenstern, Samuel B Ho, Yaron Niv
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 18 Issue 33 Pg. 4597-603 (Sep 07 2012) ISSN: 2219-2840 [Electronic] United States
• PMID: 22969235 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Gastric Mucins
• MUC5AC protein, human
• MUC6 protein, human
• Mucin 5AC
• Mucin-6

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• CD4-CD8 Ratio
• Female
• Gastric Mucins (metabolism)
• Gastric Mucosa (metabolism, pathology)
• Helicobacter Infections (complications)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Mucin 5AC (metabolism)
• Mucin-6 (metabolism)
• T-Lymphocytes (pathology)
• Ulcer (chemically induced, metabolism, microbiology)
• Young Adult